Short Communication NFkB activation, TNF-a expression, and apoptosis in the AIDS-Dementia-Complex
نویسندگان
چکیده
Tufts Neurology Program, New England Medical Center, Boston, MA 02111, USA; Department of Psychiatry, New England Medical Center, Boston, MA 02111, USA; Program in Genetics, Sackler School, Tufts University Medical School, Boston, Massachusetts, USA; Pediatric Neurology, Floating Hospital, Boston, Massachusetts, USA; Department of Pathology, University of Edinburgh, Edinburgh, Scotland, UK and Harvard School of Public Health, Boston, Massachusetts, USA
منابع مشابه
CPI-1189 prevents apoptosis and reduces glial fibrillary acidic protein immunostaining in a TNF-alpha infusion model for AIDS dementia complex.
AIDS dementia complex (ADC) is characterized by increased apoptosis, gliosis, and oxidative stress in the CNS, as well as a compromised blood-brain barrier. TNF-alpha has been shown to be elevated in AIDS dementia complex brains and may contribute to AIDS dementia complex. To model elevated TNF-alpha in AIDS dementia complex, TNF-alpha was infused ICV bilaterally into rats for 3 days. TNF-alpha...
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